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Pipeline

Dendritic Cell

Dendritic cells (DCs) are potent antigen-presenting cells that play a crucial role in initiating and regulating immune responses. In cancer immunotherapy, dendritic cell-based vaccines are designed to enhance the body’s immune system by presenting tumor-associated antigens to T cells, stimulating an effective anti-tumor response. Our autologous dendritic cell platform is being developed as an innovative approach to treat solid tumors, including lung and pancreatic cancers.

Program

Indication

Discovery

Pre-clinical

Phase 1

Phase 2

Phase 3

JY-DC001

Lung cancer

JY-DC002

Pancreatic cancer

JY-DC001 (Lung Cancer)

Program

Indication

Discovery

Pre-clinical

Phase 1

Phase 2

Phase 3

JY-DC001

Lung cancer

Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of all cases. Despite advances in targeted therapies and immune checkpoint inhibitors, many patients experience disease progression, highlighting the need for novel therapeutic approaches.  JY-DC001 is our autologous dendritic cell-based therapy, initially developed for the treatment of lung cancer. The goal is to stimulate a strong and durable anti-tumor immune response by enhancing antigen presentation and T cell activation. This therapy is designed to complement existing treatment modalities and improve clinical outcomes for patients with advanced lung cancer.  We are advancing JY-DC001 through preclinical and early clinical development, evaluating its safety, immunogenicity, and therapeutic potential.

JY-DC002 (Pancreatic Cancer)

Program

Indication

Discovery

Pre-clinical

Phase 1

Phase 2

Phase 3

JY-DC002

Pancreatic cancer

Pancreatic cancer is one of the most aggressive malignancies, often diagnosed at an advanced stage with limited treatment options. The immunosuppressive tumor microenvironment poses a significant challenge to effective immunotherapy.  JY-DC002 is our autologous dendritic cell vaccine targeting pancreatic cancer. By leveraging the antigen-presenting capabilities of dendritic cells, this therapy aims to enhance tumor-specific immune responses and overcome immune evasion mechanisms commonly observed in pancreatic tumors.  The development of JY-DC002 is focused on optimizing its therapeutic efficacy through combination strategies with existing treatments, with the goal of improving survival rates and quality of life for pancreatic cancer patients.

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